Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell cultures

Mass immunization of children in Iran with live attenuated Sugiyama measles virus adapted to calf kidney cell cultures.

Sugiyama live attenuated measles vaccine produced in bovine renal ceIls was administered during pilot studies and a mass immunization programme in Iran. Clinical observations in several of the vaccinees revealed a mild fever lasting 3-4 days which was accompanicd by the appearance of a morbilIiform rash which faded in 2 days. There was no significant difference in rcactions from subcutaneous or...

Efficacy and safety of live attenuated Sugiyama strain of measles virus in mass immunization of children in rural regions of Iran

Experimental study of a further attenuated live measles vaccine of the Sugiyama strain in Iran

Successful respiratory immunization with dry powder live-attenuated measles virus vaccine in rhesus macaques.

Measles remains an important cause of childhood mortality worldwide. Sustained high vaccination coverage is the key to preventing measles deaths. Because measles vaccine is delivered by injection, hurdles to high coverage include the need for trained medical personnel and a cold chain, waste of vaccine in multidose vials and risks associated with needle use and disposal. Respiratory vaccine del...

Measles immunization in IRAN

A New Field Trial with Two Types of Live Mealses Vaccine in Rural Regions of Iran(*)

Two further attenuated measles virus vaccines, Sugiyama and Aik strains, developed in baby calf kidney cells and in Human Diploid Cells (MRC5) respectively were compared in a field trial. Both vaccines showed c1inical evidence of attenuation and both were highly immunogenic. Problems related to the success and failure of mass immunization against measles in developing countries and in hot c1ima...